How does Victor's passion drive him to negative things?

Victor's passion for knowledge and for immortality (in the form of his reputation in the scientific community) leads to the destruction of his family and his entire life. In a quest for the "philosopher's stone," or an answer to his questions about the fine line between life and death, Victor comes up with a project in which he builds a human out of an assemblage of body parts from dead people. He brings his creation to life and is immediately horrified. He was only concerned about the scientific developments and how his name would be remembered forever for his accomplishments; he did not think about the real consequences of his actions.
Victor's creation results in tragedy after tragedy in Victor's life. For one, he loses a number of family members as a result: his brother is killed by the creature, his wife is killed by the creature on their wedding night, his best friend is also presumably murdered by the creature, and finally, his father basically dies of stress and grief after all of the other tragedies. Victor's obsession with the creature dominates his life and leads eventually to his own death. While he's building the creature, he is isolated and withdrawn, and after, he is ashamed and hiding from the consequences of his actions. At the end of the novel, Victor is wasting away in the Arctic, basically in a chase to the death between himself and the creature. The negative effects of Victor's passion are clearly depicted in the novel and result in complete tragedy for Victor and those around him.